RESEARCH ARTICLE


Change of Glomerular Hemodynamics in Patients with Advanced Chronic Kidney Disease after Cilnidipine Therapy



Atsushi Satomura, Takayuki Fujita*, Yoshinobu Fuke, Yuki Wada, Koichi Matsumoto
Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan.


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© 2009 Satomura et al;

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Correspondence: * Address correspondence to this author at the Nihon University School of Medicine, 30-1 Oyaguchi-kamimachi, Itabashiku, Tokyo, 173-8610, Japan; Tel: +81-3-3972-8111 ext. 2414; Fax: +81-3-3972-1098; E-mail: tfujita@med.nihon-u.ac.jp


Abstract

Cilnidipine, a dual calcium channel antagonist, is assumed to regulate hypertension via N- and L-type calcium channel. The N-type calcium channel is associated with sympathetic nerve activation. This effect may improve the glomerular hemodynamics in the injured nephron, and may mitigate the progression of renal injury. To clarify the effect of cilnidipine in instances of already existing decreased renal blood flow, we examined the alteration of renal hemodynamics before and after cilnidipine therapy in patients with advanced chronic kidney disease (CKD). Cilnidipine was administrated daily to 17 CKD patients with hypertension for 12 months. Another 16 patients were similarly administered amlodipine during this study, a long-acting L-type calcium channel antagonist has also been shown to be renoprotective. Glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and protein excretion in 24-hour accumulated urine were measured at the start and end of the study. The parameters of renal hemodynamics were calculated by Gomez’s estimation equation. Systolic blood pressure decreased to 80 % of the level at the beginning of the study, and ERPF increased to 127 % of the level at baseline. Glomerular capillary pressure on single nephron was reduced to 90 %, although total GFR decreased within the non-statistical change. Especially, renal vascular resistance ratio (RA/RE) on single nephron improved to 120 %. Cilnidipine improves ERPF and glomerular hypertension without worsening total renal function. N- and L-type calcium channel antagonist is effective and safe for patients with advanced CKD as a result of improvement of glomerular capillary resistance.

Keywords: N- and L-type Calcium Channel Antagonist, Glomerular Hemodynamics, Renal Vascular Resistance, Glomerular Capil-Lary Pressure, Chronic Kidney Disease.