Ascorbic Acid Supplementation and Spermatogenesis in Nigerian Men
Maria O. Ebesunun*, a, Olayiwola. B. Shittub, Oluranti A Famootob, Emmanuel O. Agbedanac, John I. Anetorc
Identifiers and Pagination:Year: 2009
First Page: 37
Last Page: 41
Publisher Id: TOCCHEMJ-2-37
Article History:Received Date: 2/9/2008
Revision Received Date: 20/12/2008
Acceptance Date: 4/5/2009
Electronic publication date: 13/8/2009
Collection year: 2009
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: The role of ascorbic acid as an antioxidant nutrient in the maturation of sperm cells has received considerable attention. A previous study from our laboratory showed reduced seminal and plasma ascorbic acid in subfertile patients.
Method: Fifteen subfertile male patients mean age 36.4±0.9 years with sperm counts of 31.4±7, 08 x106 /cm3 were given 200mg/day dose of ascorbic acid as supplement for four weeks and ten highly fertile male mean age 35.6±1.7 years with sperm count of 50.9±10.3 x106/cm3 volunteers were selected as controls. The biochemical parameters and anthropometric measurements were determined using standard methods.
Result: Significant decreases were obtained in baseline sperm cell count (p<0.01), percentage (%) motility and %vitality (p<0.01), and the % of morphologically normal sperm cells (p<0.01) in the subfertile compared with the controls. The baseline plasma and seminal ascorbic acid concentrations were significantly reduced (p<0.001). The post-supplementation sperm cell count (p<0.001), % motility and %vitality (p<0.01) were significantly increased compared with the baseline values.
Conclusion: The enhanced reversal of poor semen quality and semen ascorbic acid status with dietary supplementation of vitamin C in subfertile is a pointer to its positive role in the maintenance of sperm cell integrity. Further work is therefore required to elucidate our findings.